If you have triple-negative or basal-like breast cancer, your healthcare team will create a treatment plan just for you. However, it does have a higher risk of coming back (recurrence) within 5 years of treatment, compared to breast cancer that is hormone-receptor positive or HER-2 positive. Triple-negative breast cancer usually responds to chemotherapy. They do not spread to the lymph nodes or the bones as often as other types of breast cancer. These tumours tend to spread to the bloodstream, brain or lungs more often than breast cancers that aren’t triple negative. Many are diagnosed at a later stage when the cancer has already spread (metastasized) to lymph nodes or other organs. This means that they tend to grow and spread quickly. Most triple-negative and basal-like breast cancers are high-grade, or aggressive, tumours. Many triple-negative and basal-like breast cancers may be called interval cancers because they can develop between regularly scheduled screening mammography. Basal-like breast cancers are more likely to be found in younger women and in women of African ancestry. Women under the age of 40 and women of African or Asian ancestry have a higher risk of developing triple-negative breast cancer. But they know that it is different from other types of breast cancer. Scientists have not yet developed one internationally accepted definition of a basal-like breast cancer. They are 2 similar, but distinct, subtypes of breast cancer. And not all basal-like breast cancers are triple negative. It is important to note that not all triple-negative breast cancers are basal-like. Most basal-like breast cancers are invasive ductal carcinomas. But basal-like breast cancer cells have changes in the proteins that triple-negative breast cancers usually don’t have. Ductal carcinoma in situ (DCIS) may also be triple negative.īasal-like breast cancer is similar to triple-negative breast cancer because the cancer cells often don’t have receptors for estrogen, progesterone and HER2. Most triple-negative breast cancers are invasive ductal carcinoma. Because it doesn’t have any of these receptors, triple-negative breast cancer is considered a separate type of breast cancer with its own treatment options. Triple-negative breast cancer means that the cancer cells don’t have any of these receptors. They may also have receptors for a protein called HER2 (also called ERBB2). Many breast cancer cells have receptors for estrogen or progesterone.
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